Diabet kasalligini erta aniqlashda genetik testlarning roli
Abstract
: Ushbu maqolada 2-tip diabet kasalligini erta bosqichda aniqlashda genetik testlarning ahamiyati, ilmiy asoslari va amaliy qo‘llanilishi chuqur tahlil qilinadi. Tadqiqot doirasida TCF7L2, SLC30A8, PPARG, KCNJ11 kabi asosiy genlarning polimorfizmlari bilan diabet rivojlanishi o‘rtasidagi bog‘liqlik ko‘rib chiqildi. Shuningdek, DNK metilatsiyasi, mikroRNKlar va histon modifikatsiyalari kabi epigenetik omillar kasallik patogenezidagi roliga e’tibor qaratildi. Sun’iy intellekt va mashina o‘rganish algoritmlaridan foydalanib, genetik ma’lumotlarga asoslangan xavf baholashning aniqlik darajasi tahlil qilindi. O‘zbekiston sharoitida milliy genetik testlash tizimini yaratish, biobanklar tuzish, sog‘liqni saqlash siyosatiga integratsiya qilish va aholining genetik savodxonligini oshirish bo‘yicha takliflar ishlab chiqildi. Maqola OAK ilmiy maqola yozish talablari asosida IMRAD tuzilmasida yozilgan.
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