Cichorium intybus L. tarkibidagi kumarinlar va ularning biologik faolligi tahlili.
Abstract
Cichorium intybus L. (oddiy sikoriy) Asteraceae oilasiga mansub dorivor o‘simlik bo‘lib, xalq tabobati va zamonaviy farmatsevtika amaliyotida keng qo‘llaniladi. So‘nggi yillarda ushbu o‘simlik tarkibidagi biologik faol ikkilamchi metabolitlar, xususan, kumarinlar farmakologik jihatdan katta qiziqish uyg‘otmoqda. C. intybus tarkibida eskuletin, eskulin, skopoletin, skopolin, umbelliferon va cichoriin kabi kumarin hosilalari aniqlangan. Ushbu birikmalar kuchli antioksidant, yallig‘lanishga qarshi, antimikrob, gepatoprotektiv, antidiabetik va antitumor xususiyatlarga ega. Mazkur maqolada C. intybus tarkibidagi kumarinlarning kimyoviy tuzilishi, biosintezi, ajratib olish usullari, biologik faolligi, ta’sir mexanizmlari hamda farmatsevtik istiqbollari zamonaviy xalqaro ilmiy adabiyotlar asosida tahlil qilinadi.
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